Structural Development of Cell-Penetrating Peptides Containing Cationic Proline Derivatives
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چکیده
منابع مشابه
Cationic Cell-Penetrating Peptides Are Potent Furin Inhibitors
Cationic cell-penetrating peptides have been widely used to enhance the intracellular delivery of various types of cargoes, such as drugs and proteins. These reagents are chemically similar to the multi-basic peptides that are known to be potent proprotein convertase inhibitors. Here, we report that both HIV-1 TAT47-57 peptide and the Chariot reagent are micromolar inhibitors of furin activity ...
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ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 2018
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.c18-00079